The Best of Synthetic Biology: iGEM Gold Medals and Prizes from 2008 to 2010

by M. A. Loera-Sánchez



Grand Prize:
2007 – Pekín  Cell counter and genetic switch.
2008 – Eslovenia, Ljubljana University – Chimeric vaccines against Helicobacter pylori
2009 – University of Cambridge  Sensitivity tuners for transcriptional response and a set of biosynthetic pathways for different pigments.
2010 – Eslovenia, Ljubljana University – DNA scaffolds for spatial localization of enzymes and biochemical pathway optimization.



Best Foundational Advance:
2008  IIT Madras – Promoter library for Escherichia coli.
2009 Alberta – Synthetic Biology toolbox for artificial chromosome construction.
2010 Paris Liliane Bettencourt – Counting bacteria at poblational and cell level.

Best Presentation:
2008 Heidelberg – E. coli with chemotactic biosensor function which also produces a bactericide.
2008 Rice – Fermentation yeast that synthesize resveratrol.
2008 Washington – DNA exhange from E. coli to Saccharomyces cerevisae trough synthetic conjugation.
2009 ArtScienceBangalore – Geosmin synthesis in E. coli
2010 TU Delft – E. coli strain that tolerates, senses, dissolves and degrades alcanes.

Best Model:
2008 BCCS-Bristol – Material structuration and organization by bacteria, using chemotaxis, enviroment sensing and intercellular communication. 
2009 BCCS-Bristol – Directed protein delivery by Outer Membrane Vesicles (OMVs) 
2010 Edinburgh – Light controlled repressilator.

Best Software Tool:
2008  UC Berkeley – Clotho: sequence editor
2009 Berkeley Software – Three software tools: Eugene (language for biological construction specification), Spectacles (visual editor), Kepler Integration (workflow management)
2009 Illinois – Interactive Metabolic Pathway Tools, tool for metabolic networks design.
2010 USTC Software – iGaME: tool for model elaboration and biological system’s modules design.

Best Enviromental Project:
2008 Brown – Arsenic biosensor with electrical output.
2009 Cambridge – Coloured output generators and stimuli sensitivity tuners.
2010 Peking – Metal biosensors and whole-cell absorbents for bioremediation applications. 

Best New Biobrick Part or Device, Engineered:
2008  IIT Madras – E. coli promoter library.
2009  EPF-Lausanne – Transcription regulation through LOVtap light receptors
2009 Freiburg – Universal restriction enzymes.
2010  Slovenia – DNA scaffolds for spatial protein localization.

Best Poster:
2008  Heidelberg – E. coli biosensor and chemotaxis directed to pathogenic organisms through a quorum sensing mechanism, and bactericidal production through another quorum sensing mechanism. 
2008 UCSF – Gene silencing switch by chromatin modification (epigenetic modification) iny yeasts.
2009  Freiburg – Universal restriction enzymes.
2010 KIT Kyoto – E. coli ink for a writing pen.

Premio Mejor Estándar Nuevo:
2009 Heidelberg – Mammal BioBricks and in silico promoter design.

Premio Mejor Wiki:
2008 TU Delft – Temperature sensing E. coli through a RNA effector.
2009 Heidelberg – Mammal BioBricks and in silico promoter design.
2010 Imperial College London – Schistosoma biosensor in a Bacillus subtilis chassis.
2010 Cambridge – Reporter gene optimization.

Best Human Practices Advance:
2008  Heidelberg – E. coli biosensor and chemotaxis directed to pathogenic organisms through a quorum sensing mechanism, and bactericidal production through another quorum sensing mechanism. 
2009  Imperial College London – Report about project their project’s ethical implications.
2009 Paris – Sociological report about how sociological studies help discover ethical cuestions in Synthetic Biology.
2010 Imperial College London – Schistosoma biosensor in a Bacillus subtilis chassis.


Best Manufacturing Project:
2008 Imperial College – Light sensing and biomaterial pattern builder B. subtilis.
2009 Imperial College London E. coli strain that produces therapeutic compound and directs them to the gut.
2010 MIT – Self-assembling and self-repairing biomaterial control and production in bacteria and mammal models. 

Best Health or Medicine Project:
2008 Slovenia – Chimeric vaccines against Helicobacter pylori
2009 Stanford – Probiotic control of inflammatory bowel disease.
2010 Freiburg Bioware – Therapeutic viral vector construction kit.

Best Information Processing Project:
2009 TUDelft – Cellular communication through conjugation in E. coli.
2010 ETHZ Basel – Light controlled chemotaxis in E. coli

Best New BioBrick Part, Natural:
2008 Imperial College – Light sensing and biomaterial pattern builder B. subtilis.
2009 ULB-Brussels – Glue synthesizer E. coli strain 
2010 Minnesota – Enzyme encapsulation in bacterial microcompartments for Metabolic Engineering.

Best Experimental Measurement:
2008 Bologna – Flip-flop switch as memory genetic device.
2009 Valencia – Bioscreen: yeast culture capable of sensing and responding to electrical stimuli, producing visible images.
2010 Duke – Toolbox of genetic expression modulators, based in synthetic leucine zippers.

Best Food or Energy Project:
2008 Harvard – Carotenoids and provitamin A by endosimbionts, and also signal transfer from endosimbionts to plant cells.
2009 UNIPV-Pavia – Ethanol production from lactose in E. coli
2010 BCCS-Bristol – Nitrite and nitrate biosensor with agriculture applications.

Best New Application Area:
2008 UCSF – Genetic silencing switch through chromatin modification in yeasts.
2009 Valencia – Bioscreen: yeast culture capable of sensing and responding to electrical stimuli, producing visible images.
2010 Slovenia – DNA scaffolds for spatial localization of enzymes and biochemical pathway optimization.

     

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