December 2012 – A
|From: Ketzer, et al., (2012).|
A recent study reports the potential of synthetic riboswitches to treat cancer. Researchers used oncolytic viral vectors -i.e., viral vectors designed to proliferate specifically in tumor cells- and riboswitches to tune the expression of a therapeutic gene. Ribozymes are specially interesting because, in contrast to other regulatory elements, they do not elicit an immunological response and do not require much space in the vector.
|From: Huang, S., et al., (2012).|
MED12, a TGF-beta regulatory protein, is reported to be involved in cancer drug resistance. When MED12 is mutated, TGF-beta signaling -a pathway known to be related to drug resistance- remains active.
DNA fibers were imaged trough transmission electron microscopy (TEM) using micropatterned devices that allowed the deposition of DNA fibers suitable for TEM imaging with less background noise.