Bio! News January 2013 – B


Bio! News
January 2013 – B


From Meier, Sit and Quake, (2013).

Using a novel, cDNA-based microfluidic format instead of the two-hybrid assay for protein interactions, putative functions were assigned to 50 proteins from Streptococcus pneumoniae whose function remained unknown. After benchmarking their microfluidic device for a set of known yeast interacting protein pairs and random protein pairs, researchers determined a false-positive rate of 25% and a false-negative rate of 20% and a relatively low overlap with two-hybrid assay and AP-MS techniques for the positive pairs.

From Lewandowski, et al., (2013).

A ribosome-like machine
A rotaxane device capable of polymerizing small peptides is presented as a very primitive version of a molecular machine that shows a ribosome-like function. Although the process is far slower than the ribosome (it takes around 12 h for each amide bond to be made), researchers were able to produce a peptide at a milligram scale by running approximately 10E18 parallel machines.

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