January 2013 – C
A synthetic Schmallenberg
|From Varela et al., (2013).|
Using a Synthetic Biology approach, researchers built a synthetic variant of the Schmallenberg Virus -or SBV, an arthropod-borne virus that is associated with abortions in cattle and sheep- and used them to generate a new reverse genetics platform to study its replication cycle, tropism and virulence determinants.
|From Ye et al., (2013).|
Synthetic Biology vs metabolic syndrome
By rewiring a cellular signaling cascade to activate a bifunctional hormone (a combination of GLP-1 and leptin) using an antihypertensive drug (guanabenz), researchers from the Fussenegger group were able to relief metabolic syndrome symptoms in affected mice.
Metabolic flux sensor evidence
Experimental evidence for a metabolic flux sensor in E. coli is presented in a recent publication. Researchers argue that Fructose -1,6- bisphosphate concentration acts as a proxy of the flux through the glycolytic pathway and signals transcription factor Cre to regulate gene expression.